The word saccharin (as above) has no final "e". The word saccharine, with a final "e", is much older and is an adjective meaning "sugary" – its connection with sugar means the term is used metaphorically, often in a derogative sense, to describe something "unpleasantly over-polite" or "overly sweet". Both words are derived from the Greek word σάκχαρον (sakcharon, German "ch" sound), which ultimately derives from Sanskrit for sugar, sharkara (शर्करा), which literally means "gravel". https://secure.wikimedia.org/wikipedia/en/wiki/Saccharin#cite_note-1