But it is true that we have exchanged corpulence for starvation, and either one
will kill us. The lines of change are down. We, or at least I, can have no
conception of human life and human thought in a hundred years or fifty years.
Perhaps my greatest wisdom is the knowledge that I do not know. The sad ones
are those who waste their energy in trying to hold it back, for they can only
feel bitterness in loss and no joy in gain.

    - John Steinbeck, Travels With Charley (1962)