RULE VI: There is no body cavity that cannot be reached with a #14 needle and a good strong arm.
The house rule that is most appropriate to my daily work is RULE X, or at least the spirit of that rule. The practical application would be something like "If you don't do a P450 assay you will not find an inhibitor." or "If you don't assay the mRNA you will not find an inducer." or "If you don't check recovery you will not find covalent binding." etc. I am a big believer in "Test Early. Test Often." but this doesn't endear me to the project teams. The worst of them want to stay in full ostrich-mode as otherwise they are in danger of having their goals disrupted.
Also, my landlord is insane. He wants to rip out and replace two of my windows on Monday. It'll probably be low 30's during the day and 20's at night. My apartment relies on central (building controlled) heat and I suspect that the thermostat for it is located in someone's armpit. My landlord is insane. I am going to freeze.